Potential Role of Hyperglycemia in Fetoplacental Endothelial Dysfunction in Gestational Diabetes Mellitus | Zendy

Jian Zhou | Zendy; Xiaotian Ni | Zendy; Xiaojie Huang | Zendy; Julei Yao | Zendy; Qizhi He | Zendy; Kai Wang | Zendy; Tao Duan | Zendy

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Potential Role of Hyperglycemia in Fetoplacental Endothelial Dysfunction in Gestational Diabetes Mellitus

Author(s) -

Jian Zhou,

Xiaotian Ni,

Xiaojie Huang,

Julei Yao,

Qizhi He,

Kai Wang,

Tao Duan

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447836

Subject(s) - angiogenesis , vascular endothelial growth factor , endocrinology , medicine , fibroblast growth factor , human umbilical vein endothelial cell , umbilical vein , placental growth factor , endothelial stem cell , matrigel , placenta , mapk/erk pathway , biology , cell growth , signal transduction , microbiology and biotechnology , fetus , biochemistry , receptor , in vitro , pregnancy , genetics , vegf receptors

Gestational diabetes mellitus (GDM) is associated with structural and functional alterations in various tissues including endothelial dysfunction. The aim of this study was to explore the effects of hyperglycemia on fibroblast growth factor 2 (FGF2)- and vascular endothelial growth factor (VEGF)-stimulated placental angiogenesis and the underlying molecular signaling mechanisms.

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