Curcumin Attenuates Retinal Vascular Leakage by Inhibiting Calcium/Calmodulin-Dependent Protein Kinase II Activity in Streptozotocin-Induced Diabetes | Zendy

Jun Li | Zendy; Peipei Wang | Zendy; Ying Jia | Zendy; Zhen Chen | Zendy; Songping Yu | Zendy

Open Access

Curcumin Attenuates Retinal Vascular Leakage by Inhibiting Calcium/Calmodulin-Dependent Protein Kinase II Activity in Streptozotocin-Induced Diabetes

Author(s) -

Jun Li,

Peipei Wang,

Ying Jia,

Zhen Chen,

Songping Yu

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447826

Subject(s) - curcumin , streptozotocin , chemistry , vascular endothelial growth factor , retinal , calcium in biology , medicine , endocrinology , pharmacology , calcium , biology , diabetes mellitus , biochemistry , vegf receptors

Curcumin possesses many pharmacological properties including anti-inflammatory effects. Although prior studies indicate that curcumin has beneficial effects for diabetic retinopathy, the mechanism of action is not known. To address this issue, we investigated the effect of curcumin against diabetes-induced retinal vascular damage and its mechanism of action by using cultured retinal Müller cells stimulated with high glucose.

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