Forkhead Box Protein C2 Promotes Epithelial-Mesenchymal Transition, Migration and Invasion in Cisplatin-Resistant Human Ovarian Cancer Cell Line (SKOV3/CDDP) | Zendy

Chanjuan Li | Zendy; Hongjuan Ding | Zendy; Jing Tian | Zendy; Lili Wu | Zendy; Yun Wang | Zendy; Xing Yuan | Zendy; Min Chen | Zendy

Open Access

Forkhead Box Protein C2 Promotes Epithelial-Mesenchymal Transition, Migration and Invasion in Cisplatin-Resistant Human Ovarian Cancer Cell Line (SKOV3/CDDP)

Author(s) -

Chanjuan Li,

Hongjuan Ding,

Jing Tian,

Lili Wu,

Yun Wang,

Xing Yuan,

Min Chen

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447818

Subject(s) - gene knockdown , epithelial–mesenchymal transition , small hairpin rna , cancer research , downregulation and upregulation , cisplatin , ovarian cancer , cell culture , cell migration , chemistry , protein kinase b , cell growth , matrigel , cell , biology , microbiology and biotechnology , cancer , signal transduction , angiogenesis , biochemistry , genetics , chemotherapy , gene

Forkhead Box Protein C2 (FOXC2) has been reported to be overexpressed in a variety of human cancers. However, it is unclear whether FOXC2 regulates epithelial-mesenchymal transition (EMT) in CDDP-resistant ovarian cancer cells. The aim of this study is to investigate the effects of FOXC2 on EMT and invasive characteristics of CDDP-resistant ovarian cancer cells and the underlying molecular mechanism.

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