Stimulated Suicidal Erythrocyte Death in Arteritis | Zendy

Rosi Bissinger | Zendy; Daniela Kempe-Teufel | Zendy; Sabina Honisch | Zendy; Syed M. Qadri | Zendy; Elko Randrianarisoa | Zendy; HansUlrich Häring | Zendy; Jörg Henes | Zendy; Florian Läng | Zendy

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Stimulated Suicidal Erythrocyte Death in Arteritis

Author(s) -

Rosi Bissinger,

Daniela Kempe-Teufel,

Sabina Honisch,

Syed M. Qadri,

Elko Randrianarisoa,

HansUlrich Häring,

Jörg Henes,

Florian Läng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447814

Subject(s) - oxidative stress , phosphatidylserine , ceramide , reactive oxygen species , medicine , endocrinology , anemia , arteritis , chemistry , apoptosis , biochemistry , phospholipid , membrane

Arteritis is an inflammatory disease of the vascular wall leading to ischemia and vascular occlusion. Complications of arteritis include anemia, which could, at least in theory, result from suicidal erythrocyte death or eryptosis, which is characterized by erythrocyte shrinkage and phosphatidylserine (PS) exposure at the erythrocyte surface. Cellular mechanisms involved in the stimulation of eryptosis include increased cytosolic Ca2+-concentration ([Ca2+]i), oxidative stress and ceramide formation. The present study explored whether and how arteritis influences eryptosis.

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