α-Solanine Modulates the Radiosensitivity of Esophageal Cancer Cells by Inducing MicroRNA 138 Expression | Zendy

Yuanyuan Wang | Zendy; Jianbo Wu | Zendy; Wei Guo | Zendy; Qianqian Sun | Zendy; Xiaonan Chen | Zendy; Wenqiao Zang | Zendy; Ziming Dong | Zendy; Guoqiang Zhao | Zendy

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α-Solanine Modulates the Radiosensitivity of Esophageal Cancer Cells by Inducing MicroRNA 138 Expression

Author(s) -

Yuanyuan Wang,

Jianbo Wu,

Wei Guo,

Qianqian Sun,

Xiaonan Chen,

Wenqiao Zang,

Ziming Dong,

Guoqiang Zhao

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447807

Subject(s) - radiosensitivity , survivin , comet assay , flow cytometry , apoptosis , chemistry , cancer research , cytotoxic t cell , viability assay , cancer cell , microbiology and biotechnology , downregulation and upregulation , radiation sensitivity , cancer , biology , dna damage , radiation therapy , in vitro , medicine , irradiation , dna , biochemistry , genetics , physics , gene , nuclear physics

Esophageal cancer (EC) is one of the most common malignant tumors in the world. Due to difficulties with performing the operation, most patients choose to have palliative treatment instead. Radiotherapy is one of the main palliative treatments of EC. However, the clinical efficacy of radiotherapy is not satisfactory α-Solanine is a bioactive component of steroidal glycoalkaloids which has been demonstrated to exhibit anti-metastasis activity in different cancers. In the present study, we determined the effect of α-solanine on the radiosensitivity of EC cells and priliminarily explored the underlying molecular mechanisms.

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