Palmitate-Induced MMP-9 Expression in the Human Monocytic Cells is Mediated through the TLR4-MyD88 Dependent Mechanism | Zendy

Sardar Sindhu | Zendy; Areej Al-Roub | Zendy; Merin Koshy | Zendy; Reeby Thomas | Zendy; Rasheed Ahmad | Zendy

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Palmitate-Induced MMP-9 Expression in the Human Monocytic Cells is Mediated through the TLR4-MyD88 Dependent Mechanism

Author(s) -

Sardar Sindhu,

Areej Al-Roub,

Merin Koshy,

Reeby Thomas,

Rasheed Ahmad

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447798

Subject(s) - tlr4 , matrix metalloproteinase , inflammation , gene silencing , thp1 cell line , monocyte , endocrinology , blot , medicine , cell culture , chemistry , tumor necrosis factor alpha , palmitic acid , microbiology and biotechnology , biology , fatty acid , biochemistry , gene , genetics

Obese individuals are known to have increased Matrix metalloproteinase (MMP)-9 plasma levels and MMP-9 is reported to play an important role in obesity-associated adipose tissue inflammation. Since in obesity, the levels of circulatory saturated free fatty acid (FFA) palmitate (palimitic acid) are increased and modulate the expression of inflammatory mediators, the role of palmitate in the regulation of MMP-9 remains unclear.

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