A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities | Zendy

Youlin Deng | Zendy; Zhongliang Wang | Zendy; Fugui Zhang | Zendy; Min Qiao | Zendy; Zhengjian Yan | Zendy; Qiang Wei | Zendy; Jing Wang | Zendy; Hao Liu | Zendy; Jiaming Fan | Zendy; Yulong Zou | Zendy; Junyi Liao | Zendy; Xue Hu | Zendy; LiQun Chen | Zendy; Xinyi Yu | Zendy; Rex C. Haydon | Zendy; Hue H. Luu | Zendy; Hongbo Qi | Zendy; TongChuan He | Zendy; Junhui Zhang | Zendy

Open Access

A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities

Author(s) -

Youlin Deng,

Zhongliang Wang,

Fugui Zhang,

Min Qiao,

Zhengjian Yan,

Qiang Wei,

Jing Wang,

Hao Liu,

Jiaming Fan,

Yulong Zou,

Junyi Liao,

Xue Hu,

LiQun Chen,

Xinyi Yu,

Rex C. Haydon,

Hue H. Luu,

Hongbo Qi,

TongChuan He,

Junhui Zhang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447797

Subject(s) - niclosamide , ovarian cancer , cancer research , cell growth , cell cycle , apoptosis , signal transduction , gene silencing , cancer , cancer cell , medicine , pharmacology , biology , microbiology and biotechnology , ecology , biochemistry , genetics , gene

Ovarian cancer is the most lethal gynecologic malignancy, and there is an unmet clinical need to develop new therapies. Although showing promising anticancer activity, Niclosamide may not be used as a monotherapy. We seek to investigate whether inhibiting IGF signaling potentiates Niclosamide's anticancer efficacy in human ovarian cancer cells.

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