WNK3 Kinase Enhances the Sodium Chloride Cotransporter Expression via an ERK 1/2 Signaling Pathway | Zendy

Dexuan Wang | Zendy; Yiqian Zhang | Zendy; Jin-Hua Han | Zendy; Shufang Pan | Zendy; Ning Xu | Zendy; Xiuyan Feng | Zendy; Zhizhi Zhuang | Zendy; Courtney M. Caroti | Zendy; Jieqiu Zhuang | Zendy; Robert S. Hoover | Zendy; Dingying Gu | Zendy; Qiyi Zeng | Zendy; Hui Cai | Zendy

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WNK3 Kinase Enhances the Sodium Chloride Cotransporter Expression via an ERK 1/2 Signaling Pathway

Author(s) -

Dexuan Wang,

Yiqian Zhang,

Jin-Hua Han,

Shufang Pan,

Ning Xu,

Xiuyan Feng,

Zhizhi Zhuang,

Courtney M. Caroti,

Jieqiu Zhuang,

Robert S. Hoover,

Dingying Gu,

Qiyi Zeng,

Hui Cai

Publication year - 2016

Publication title -

the nephron journals/nephron journals

Language(s) - English

Resource type - Journals

eISSN - 2235-3186

pISSN - 1660-8151

DOI - 10.1159/000447717

Subject(s) - cycloheximide , kinase , cotransporter , mapk/erk pathway , phosphorylation , protein kinase a , microbiology and biotechnology , endocrinology , medicine , chemistry , biology , sodium , protein biosynthesis , organic chemistry

WNK kinase is a serine/threonine kinase that plays an important role in normal blood pressure homeostasis. WNK3 was previously found to enhance the activity of sodium chloride cotransporter (NCC) in Xenopus oocyte. However, the mechanism through which it works remains unclear.

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