Topical Treatment of Infantile Haemangiomas: A Comparative Study on the Selection of a Semi-Solid Vehicle | Zendy

Antonella Casiraghi | Zendy; Umberto M. Musazzi | Zendy; Paolo Rocco | Zendy; Silvia Franzé | Zendy; Paola Minghetti | Zendy

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Topical Treatment of Infantile Haemangiomas: A Comparative Study on the Selection of a Semi-Solid Vehicle

Author(s) -

Antonella Casiraghi,

Umberto M. Musazzi,

Paolo Rocco,

Silvia Franzé,

Paola Minghetti

Publication year - 2016

Publication title -

skin pharmacology and physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.703

H-Index - 74

eISSN - 1660-5535

pISSN - 1660-5527

DOI - 10.1159/000447672

Subject(s) - permeation , chemistry , epidermis (zoology) , human skin , penetration (warfare) , pharmacology , propranolol hydrochloride , hydrochloride , in vitro , drug , propranolol , chromatography , dermatology , medicine , biochemistry , biology , anatomy , genetics , operations research , membrane , engineering

Topical β-blockers have recently been proposed as a valid alternative to oral drugs for treating cutaneous infantile haemangiomas, but clinical results in the literature are inconsistent due to the empirical choice of topical preparations. The current investigation aimed to rationalize the selection of a semi-solid vehicle for a locally applied drug product containing 1% w/w propranolol hydrochloride (PR-Cl).

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