Endothelial Dysfunction in Renal Interstitial Fibrosis | Zendy

Heather M. Perry | Zendy; Mark D. Okusa | Zendy

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Endothelial Dysfunction in Renal Interstitial Fibrosis

Author(s) -

Heather M. Perry,

Mark D. Okusa

Publication year - 2016

Publication title -

the nephron journals/nephron journals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.951

H-Index - 72

eISSN - 2235-3186

pISSN - 1660-8151

DOI - 10.1159/000447607

Subject(s) - medicine , fibrosis , acute kidney injury , kidney disease , kidney , endothelium , inflammation , pathological , crosstalk , hypoxia (environmental) , nephrology , disease , pathology , bioinformatics , biology , chemistry , physics , organic chemistry , oxygen , optics

Kidney disease affects millions of people worldwide and it is now widely accepted that many pathological processes may persist after acute kidney injury that can cause the progression to CKD. Tubulointerstitial fibrosis manifests soon after injury and while many cellular and molecular components of kidney fibrosis have been discovered, largely in animal models, new therapeutic strategies are still desperately needed. The renal endothelium has emerged as important in progression of fibrosis through regulation of hypoxia, inflammation and cellular crosstalk. This review aims to highlight our current understanding of the role of the endothelium in interstitial fibrosis and to identify potential therapeutic targets. © 2016 S. Karger AG, Basel.

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