Aging Male Spontaneously Hypertensive Rat as an Animal Model for the Evaluation of the Interplay between Contrast-Induced Acute Kidney Injury and Cardiorenal Syndrome in Humans | Zendy

Jun Zhang | Zendy; Mohammad Kazem Fallahzadeh | Zendy; Peter A. McCullough | Zendy

Open Access

Aging Male Spontaneously Hypertensive Rat as an Animal Model for the Evaluation of the Interplay between Contrast-Induced Acute Kidney Injury and Cardiorenal Syndrome in Humans

Author(s) -

Jun Zhang,

Mohammad Kazem Fallahzadeh,

Peter A. McCullough

Publication year - 2016

Publication title -

cardiorenal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.661

H-Index - 21

eISSN - 1664-3828

pISSN - 1664-5502

DOI - 10.1159/000447542

Subject(s) - medicine , cardiorenal syndrome , acute kidney injury , biomarker , heart failure , lipocalin , kidney disease , pathogenesis , endothelial dysfunction , contrast induced nephropathy , bioinformatics , cardiology , endocrinology , nephropathy , diabetes mellitus , biochemistry , chemistry , biology

Although there are some animal models for biomarkers of contrast-induced acute kidney injury (CI-AKI), for cardiorenal syndrome (CRS) and for acute renal failure, the interplay between CI-AKI and CRS has yet to be evaluated. Insight into the pathogenesis of CRS is urgently needed from animal models in order to foster the discovery and implementation of novel biomarkers for this disease. Specially designed animal models for type 1 and 3 CRS, particularly CI-AKI, have not yet emerged.

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