Paris Polyphylla -Derived Saponins Inhibit Growth of Bladder Cancer Cells by Inducing Mutant P53 Degradation While Up-Regulating CDKN1A Expression | Zendy

Yanxia Guo | Zendy; Zhiyong Liu | Zendy; Kailin Li | Zendy; Guangshang Cao | Zendy; Chao Sun | Zendy; Guanghui Cheng | Zendy; Denglu Zhang | Zendy; Wei Peng | Zendy; Jiaxin Liu | Zendy; Yuanfu Qi | Zendy; Lu Zhang | Zendy; Peng Wang | Zendy; Yuan Chen | Zendy; ZhaoMin Lin | Zendy; Yong Guan | Zendy; Jianye Zhang | Zendy; Jiliang Wen | Zendy; Fang Wang | Zendy; Feng Kong | Zendy; Dawei Xu | Zendy; Shengtian Zhao | Zendy

Open Access

Paris Polyphylla -Derived Saponins Inhibit Growth of Bladder Cancer Cells by Inducing Mutant P53 Degradation While Up-Regulating CDKN1A Expression

Author(s) -

Yanxia Guo,

Zhiyong Liu,

Kailin Li,

Guangshang Cao,

Chao Sun,

Guanghui Cheng,

Denglu Zhang,

Wei Peng,

Jiaxin Liu,

Yuanfu Qi,

Lu Zhang,

Peng Wang,

Yuan Chen,

ZhaoMin Lin,

Yong Guan,

Jianye Zhang,

Jiliang Wen,

Fang Wang,

Feng Kong,

Dawei Xu,

Shengtian Zhao

Publication year - 2018

Publication title -

current urology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.476

H-Index - 13

eISSN - 1661-7657

pISSN - 1661-7649

DOI - 10.1159/000447207

Subject(s) - clonogenic assay , cell cycle , mutant , cell growth , medicine , cancer research , cell , microbiology and biotechnology , pharmacology , biology , biochemistry , gene

Paris polyphylla var. yunnanensis (PPVY), a Chinese herb, has long been used for cancer treatment, and its steroidal saponins are suggested to exert an anti-tumor activity, however, the underlying mechanism is incompletely understood and their effect on bladder cancer (BC) remains unknown. The present study is thus designed to address these issues.

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