Obesity, Renin-Angiotensin System Blockade and Risk of Adverse Renal Outcomes: A Population-Based Cohort Study | Zendy

Jordana B. Cohen | Zendy; Alisa J. StephensShields | Zendy; Michelle Denburg | Zendy; Amanda H. Anderson | Zendy; Raymond R. Townsend | Zendy; Peter P. Reese | Zendy

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Obesity, Renin-Angiotensin System Blockade and Risk of Adverse Renal Outcomes: A Population-Based Cohort Study

Author(s) -

Jordana B. Cohen,

Alisa J. StephensShields,

Michelle Denburg,

Amanda H. Anderson,

Raymond R. Townsend,

Peter P. Reese

Publication year - 2016

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000446862

Subject(s) - medicine , hazard ratio , renal function , proportional hazards model , retrospective cohort study , kidney disease , cohort , population , blockade , cohort study , diabetes mellitus , endocrinology , confidence interval , receptor , environmental health

Obesity substantially increases the risk of the development of chronic kidney disease. Adipose tissue expresses all of the components of the renin-angiotensin system (RAS), contributing to the high prevalence of hypertension in obese patients and driving renal hyperfiltration and subsequent glomerular injury.

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