Prognostic Value of ADAMTS Proteases and Their Substrates in Epithelial Ovarian Cancer | Zendy

Maíra A. Lima | Zendy; Liliane dos Santos | Zendy; José Antônio Orellana Turri | Zendy; Suely ogaki | Zendy; Marcilei Buim | Zendy; Joema Felipe Lima | Zendy; João de Jesus Viana Pinheiro | Zendy; Cynthia Aparecida Bueno de Toledo Osório | Zendy; Fernando Augusto Soares | Zendy; Vanessa M. Freitas | Zendy

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Prognostic Value of ADAMTS Proteases and Their Substrates in Epithelial Ovarian Cancer

Author(s) -

Maíra A. Lima,

Liliane dos Santos,

José Antônio Orellana Turri,

Suely ogaki,

Marcilei Buim,

Joema Felipe Lima,

João de Jesus Viana Pinheiro,

Cynthia Aparecida Bueno de Toledo Osório,

Fernando Augusto Soares,

Vanessa M. Freitas

Publication year - 2016

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000446244

Subject(s) - versican , adamts , thrombospondin , ovarian cancer , immunohistochemistry , proteases , cancer research , disintegrin , metalloproteinase , cancer , biology , proteoglycan , medicine , matrix metalloproteinase , immunology , extracellular matrix , enzyme , biochemistry

ADAMTS are metalloproteases with disintegrin and thrombospondin motifs. They are secreted proteases playing a role in biological processes such as inflammation, angiogenesis, and urogenital development. ADAMTS have specific substrates, such as the proteoglycans (PG) versican, aggrecan, and brevican. Despite data indicating a role of ADAMTS in tumor invasion and metastases, effects played by these molecules in cancer progression are still controversial. In ovarian cancer, the importance of ADAMTS gene mutations was recently described and related to chemotherapy outcome.

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