DCP-LA Exerts an Antiaging Action on the Skin | Zendy

Tomoyuki Nishizaki | Zendy

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DCP-LA Exerts an Antiaging Action on the Skin

Author(s) -

Tomoyuki Nishizaki

Publication year - 2016

Publication title -

skin pharmacology and physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.703

H-Index - 74

eISSN - 1660-5535

pISSN - 1660-5527

DOI - 10.1159/000446216

Subject(s) - sodium nitroprusside , senescence , nitric oxide , chemistry , human skin , keratinocyte , cell , viability assay , pharmacology , biochemistry , microbiology and biotechnology , biology , in vitro , genetics , organic chemistry

The present study assessed the possibility for the linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) as an antiaging compound for the skin by assaying senescence-associated β-galactosidase (SA-β-Gal), a biomarker of senescence and cell viability. The nitric oxide (NO) donor sodium nitroprusside (SNP) increased in SA-β-Gal-positive cells in cultured human fibroblasts and mouse keratinocytes, and DCP-LA significantly inhibited the effect of SNP. Moreover, SNP induced cell death in cultured mouse keratinocytes, and DCP-LA significantly prevented NO stress-induced death of keratinocytes. Taken together, these results indicate that DCP-LA exerts an antiaging action on the skin.

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