Preventive Ceftriaxone in Patients with Stroke Treated with Intravenous Thrombolysis: Post Hoc Analysis of the Preventive Antibiotics in Stroke Study | Zendy

JanDirk Vermeij | Zendy; Willeke F. Westendorp | Zendy; Yvo B.W.E.M. Roos | Zendy; Matthijs C. Brouwer | Zendy; Diederik van de Beek | Zendy; Paul J. Nederkoorn | Zendy

Open Access

Preventive Ceftriaxone in Patients with Stroke Treated with Intravenous Thrombolysis: Post Hoc Analysis of the Preventive Antibiotics in Stroke Study

Author(s) -

JanDirk Vermeij,

Willeke F. Westendorp,

Yvo B.W.E.M. Roos,

Matthijs C. Brouwer,

Diederik van de Beek,

Paul J. Nederkoorn

Publication year - 2016

Publication title -

cerebrovascular diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.221

H-Index - 104

eISSN - 1421-9786

pISSN - 1015-9770

DOI - 10.1159/000446160

Subject(s) - medicine , ceftriaxone , post hoc analysis , modified rankin scale , stroke (engine) , antibiotics , subgroup analysis , randomized controlled trial , clinical endpoint , thrombolysis , surgery , confidence interval , ischemic stroke , mechanical engineering , ischemia , myocardial infarction , microbiology and biotechnology , biology , engineering

The Preventive Antibiotics in Stroke Study (PASS), a randomized open-label masked endpoint trial, showed that preventive ceftriaxone did not improve functional outcome at 3 months in patients with acute stroke (adjusted common OR 0.95; 95% CI 0.82-1.09). Post-hoc analyses showed that among patients who received intravenous thrombolysis (IVT), patients who received ceftriaxone had a significantly better outcome as compared with the control group. This study aimed to gain more insight into the characteristics of these patients.

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