Genetic Variants in Toll-Like Receptor 4 Gene and Their Association Analysis with Estimated Glomerular Filtration Rate in Mexican American Families | Zendy

Farook Thameem | Zendy; Sobha Puppala | Zendy; Vidya S. Farook | Zendy; Balakuntalam S. Kasinath | Zendy; John Blangero | Zendy; Ravindranath Duggirala | Zendy; Hanna E. Abboud | Zendy

Open Access

Genetic Variants in Toll-Like Receptor 4 Gene and Their Association Analysis with Estimated Glomerular Filtration Rate in Mexican American Families

Author(s) -

Farook Thameem,

Sobha Puppala,

Vidya S. Farook,

Balakuntalam S. Kasinath,

John Blangero,

Ravindranath Duggirala,

Hanna E. Abboud

Publication year - 2016

Publication title -

cardiorenal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.661

H-Index - 21

eISSN - 1664-3828

pISSN - 1664-5502

DOI - 10.1159/000445754

Subject(s) - renal function , tlr4 , medicine , genotype , genetic association , immunology , receptor , endocrinology , single nucleotide polymorphism , gene , biology , genetics

Toll-like receptor 4 (TLR4) is one of the regulators of the innate immune response. Genetic variations in TLR4 have been associated with inflammatory diseases, including type 2 diabetes. However, to our knowledge, there are no reports on the role of variations in TLR4 in chronic kidney disease susceptibility. The objective of this study is to determine whether the genetic variants in TLR4 are associated with the estimated glomerular filtration rate (eGFR), a measure of renal function.

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