NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN | Zendy

Xiaofeng Hang | Zendy; Shanbang Zhu | Zendy; DI Hong-wei | Zendy; Zhiqin Wu | Zendy; Kaijian Chu | Zendy; Junxue Wang | Zendy; Haiguang Xin | Zendy; Guanzhen Yu | Zendy; Haoran Peng | Zendy; Xiaohui Miao | Zendy; Wensheng Xu | Zendy

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NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN

Author(s) -

Xiaofeng Hang,

Shanbang Zhu,

DI Hong-wei,

Zhiqin Wu,

Kaijian Chu,

Junxue Wang,

Haiguang Xin,

Guanzhen Yu,

Haoran Peng,

Xiaohui Miao,

Wensheng Xu

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445667

Subject(s) - pten , cancer research , nedd4 , hepatocellular carcinoma , tensin , cell growth , gene silencing , cell , biology , carcinogenesis , cancer , medicine , pi3k/akt/mtor pathway , signal transduction , ubiquitin , microbiology and biotechnology , ubiquitin ligase , gene , biochemistry , genetics

Neural precursor cell-expressed developmentally down-regulated gene 4 (NEDD4) plays an important role in tumor cell growth, yet its role in hepatocellular carcinoma (HCC) remains unclear. This study is to establish NEDD4 as a prognostic biomarker by which the survival of HCC patients can be predicted and to reveal the role of NEDD4 in hepatocellular carcinoma cell growth.

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