Open AccessCYP2J2-Derived EETs Attenuated Angiotensin II-Induced Adventitial Remodeling via Reduced Inflammatory Response
Author(s) -
Chi Zhou,
Jin Huang,
Junxiong Chen,
Jinsheng Lai,
Fasheng Zhu,
Xizhen Xu,
Dao Wen Wang
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000445663
Subject(s) - angiotensin ii , chemistry , socs3 , adventitia , microbiology and biotechnology , signal transduction , phosphorylation , stat3 , pharmacology , endocrinology , medicine , biology , receptor , biochemistry
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acids (AA) to form epoxyeicosatrienoic acids (EETs), which exert beneficial roles in the treatment of cardiovascular diseases, but little is known about its role on adventitial remodeling.
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