Storage of Erythrocytes Induces Suicidal Erythrocyte Death | Zendy

Elisabeth Lang | Zendy; Vitaly I. Pozdeev | Zendy; Haifeng Xu | Zendy; Prashant V. Shinde | Zendy; Kristina Behnke | Zendy; Junnat Hamdam | Zendy; Erik Lehnert | Zendy; Rüdiger E. Scharf | Zendy; Florian Läng | Zendy; Dieter Häussinger | Zendy; Karl S. Lang | Zendy; Philipp A. Lang | Zendy

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Storage of Erythrocytes Induces Suicidal Erythrocyte Death

Author(s) -

Elisabeth Lang,

Vitaly I. Pozdeev,

Haifeng Xu,

Prashant V. Shinde,

Kristina Behnke,

Junnat Hamdam,

Erik Lehnert,

Rüdiger E. Scharf,

Florian Läng,

Dieter Häussinger,

Karl S. Lang,

Philipp A. Lang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445657

Subject(s) - medicine , biology , microbiology and biotechnology

Similar to apoptosis of nucleated cells, red blood cells (RBC) can undergo suicidal cell death - called eryptosis. It is characterized by cell shrinkage and phosphatidylserine translocation. Eryptosis is triggered by an increase of intracellular calcium concentration due to activation of nonselective cation channels. The cation channels and consequently eryptosis are inhibited by erythropoietin. Eryptotic RBC are engulfed by macrophages and thus rapidly cleared from circulating blood. In this study, we explored whether storage of RBC influences the rate of eryptosis.

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