Micafungin-Induced Suicidal Erythrocyte Death | Zendy

Thomas Peter | Zendy; Rosi Bissinger | Zendy; Elena Signoretto | Zendy; Andreas F. Mack | Zendy; Florian Läng | Zendy

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Micafungin-Induced Suicidal Erythrocyte Death

Author(s) -

Thomas Peter,

Rosi Bissinger,

Elena Signoretto,

Andreas F. Mack,

Florian Läng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445650

Subject(s) - phosphatidylserine , protein kinase c , ceramide , biology , chemistry , biochemistry , pharmacology , apoptosis , microbiology and biotechnology , kinase , phospholipid , membrane

The antifungal drug Micafungin is used for the treatment of diverse fungal infections including candidiasis and aspergillosis. Side effects of Micafungin treatment include microangiopathic hemolytic anemia and thrombocytopenia with microvascular thrombosis. The development of thrombosis may be fostered by stimulation of eryptosis, the suicidal death of erythrocytes characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Triggers of eryptosis include increase of cytosolic Ca2+ activity ([Ca2+]i), oxidative stress, ceramide, activated protein kinase C (PKC), casein kinase 1α or p38 kinase and activated caspases. The present study explored, whether Micafungin induces eryptosis.

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