Verteporfin can Reverse the Paclitaxel Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression | Zendy

Wang Pan | Zendy; Qian Wang | Zendy; Yi Zhang | Zendy; Naishu Zhang | Zendy; Jiamin Qin | Zendy; Wěi Li | Zendy; Jing Wang | Zendy; Fangfang Wu | Zendy; Lingsen Cao | Zendy; Guanglin Xu | Zendy

Open Access

Verteporfin can Reverse the Paclitaxel Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression

Author(s) -

Wang Pan,

Qian Wang,

Yi Zhang,

Naishu Zhang,

Jiamin Qin,

Wěi Li,

Jing Wang,

Fangfang Wu,

Lingsen Cao,

Guanglin Xu

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445640

Subject(s) - verteporfin , paclitaxel , cytotoxicity , transfection , cancer research , cell culture , apoptosis , gene silencing , cancer cell , cell growth , biology , microbiology and biotechnology , chemistry , medicine , in vitro , cancer , biochemistry , retinal , genetics , choroidal neovascularization , gene

Paclitaxel (PTX) is one of the most effective anti-cancer drugs. However, multiple drug resistance is still the main factor that hinders the effective treatment of cancer with PTX. Several factors including YAP over-expression can cause PTX resistance. In this study, we aimed to verify the role YAP plays in PTX resistance, explore the reversal of PTX resistance by verteporfin (VP) and investigate the effect of combination therapy of PTX and VP on the PTX resistant colon cancer cells (HCT-8/T).

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