Geniposide Prevents Hypoxia/Reoxygenation-Induced Apoptosis in H9c2 Cells: Improvement of Mitochondrial Dysfunction and Activation of GLP-1R and the PI3K/AKT Signaling Pathway | Zendy

Youqin Jiang | Zendy; Guanglei Chang | Zendy; Ying Wang | Zendy; Dongying Zhang | Zendy; Li Cao | Zendy; Jian Liu | Zendy

Open Access

Geniposide Prevents Hypoxia/Reoxygenation-Induced Apoptosis in H9c2 Cells: Improvement of Mitochondrial Dysfunction and Activation of GLP-1R and the PI3K/AKT Signaling Pathway

Author(s) -

Youqin Jiang,

Guanglei Chang,

Ying Wang,

Dongying Zhang,

Li Cao,

Jian Liu

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445634

Subject(s) - propidium iodide , viability assay , apoptosis , reactive oxygen species , cytochrome c , protein kinase b , oxidative stress , mitochondrial permeability transition pore , annexin , mitochondrion , microbiology and biotechnology , superoxide dismutase , chemistry , mitochondrial fission , biology , pi3k/akt/mtor pathway , programmed cell death , biochemistry

Myocardial ischemia/reperfusion injury is a major cause of morbidity and mortality associated with coronary heart disease. Many studies have demonstrated that natural products are promising chemotherapeutic drugs counteracting the loss of cardiomyocytes. Thus, the purpose of the present study was to investigate the effects of geniposide, a traditional Chinese herb extract from Gardenia jasminoides J. Ellis, on cardiomyocyte apoptosis induced by hypoxia/reoxygenation (H/R) in H9c2 cells, and their underlying mechanisms.

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