Open AccessModulation of MAPK and NF-κB Signaling Pathways by Antioxidant Therapy in Skeletal Muscle of Heart Failure Rats
Author(s) -
Paula Felippe Martinez,
Camila Bonomo,
Daniele M. Guizoni,
S. A. Oliveira,
R. L. Damatto,
M. D. M. Cezar,
A. R. R. Lima,
Luana Urbano Pagan,
Fábio Rodrigues Ferreira Seiva,
Renata T. Bueno,
Denise C. Fernandes,
Francisco Rafael Martins Laurindo,
Leonardo A. M. Zornoff,
Katashi Okoshi,
Marina Politi Okoshi
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000445631
Subject(s) - oxidative stress , soleus muscle , medicine , endocrinology , acetylcysteine , skeletal muscle , heart failure , p38 mitogen activated protein kinases , western blot , mapk/erk pathway , antioxidant , signal transduction , chemistry , biochemistry , gene
Although increased oxidative stress plays a role in heart failure (HF)-induced skeletal myopathy, signaling pathways involved in muscle changes and the role of antioxidant agents have been poorly addressed. We evaluated the effects of N-acetylcysteine (NAC) on intracellular signaling pathways potentially modulated by oxidative stress in soleus muscle from HF rats.
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