Liver X Receptor Agonist TO901317 Prevents Diacylglycerols Accumulation in the Heart of Streptozotocin-Diabetic Rats | Zendy

Dorota Harasiuk | Zendy; Marcin Baranowski | Zendy; Piotr Zabielski | Zendy; Adrian Chabowski | Zendy; J Górski | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Liver X Receptor Agonist TO901317 Prevents Diacylglycerols Accumulation in the Heart of Streptozotocin-Diabetic Rats

Author(s) -

Dorota Harasiuk,

Marcin Baranowski,

Piotr Zabielski,

Adrian Chabowski,

J Górski

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445629

Subject(s) - liver x receptor , endocrinology , medicine , streptozotocin , agonist , adipose triglyceride lipase , lipid metabolism , chemistry , cholesterol , diabetes mellitus , triglyceride , receptor , nuclear receptor , biochemistry , transcription factor , gene

Liver X receptors (LXRα and LXRβ) are ligand-activated transcription factors that regulate expression of genes involved in lipid and cholesterol metabolism. LXR expression has been identified in the heart, and enhanced LXR activity in the streptozotocin (STZ) diabetic myocardium was reported recently. The aim of this study was to investigate effect of in vivo LXR activation on myocardial lipid metabolism under conditions of STZ-induced diabetes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research