Acetylcholine Attenuates Hydrogen Peroxide-Induced Intracellular Calcium Dyshomeostasis Through Both Muscarinic and Nicotinic Receptors in Cardiomyocytes | Zendy

Siripong Palee | Zendy; Nattayaporn Apaijai | Zendy; Krekwit Shinlapawittayatorn | Zendy; Siriporn C. Chattipakorn | Zendy; Nipon Chattipakorn | Zendy

Open Access

Acetylcholine Attenuates Hydrogen Peroxide-Induced Intracellular Calcium Dyshomeostasis Through Both Muscarinic and Nicotinic Receptors in Cardiomyocytes

Author(s) -

Siripong Palee,

Nattayaporn Apaijai,

Krekwit Shinlapawittayatorn,

Siriporn C. Chattipakorn,

Nipon Chattipakorn

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445628

Subject(s) - muscarinic acetylcholine receptor , acetylcholine , intracellular , mecamylamine , chemistry , muscarinic acetylcholine receptor m3 , calcium in biology , nicotinic agonist , atropine , oxidative stress , pharmacology , endocrinology , medicine , receptor , biochemistry , biology

Oxidative stress induced intracellular Ca2+ overload plays an important role in the pathophysiology of several heart diseases. Acetylcholine (ACh) has been shown to suppress reactive oxygen species generation during oxidative stress. However, there is little information regarding the effects of ACh on the intracellular Ca2+ regulation in the presence of oxidative stress. Therefore, we investigated the effects of ACh applied before or after hydrogen peroxide (H2O2) treatment on the intracellular Ca2+ regulation in isolated cardiomyocytes.

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