The Effect Of NO Donor on Calcium Uptake and Reactive Nitrogen Species Production in Mitochondria | Zendy

Akopova Ov | Zendy; Anatoly Kotsiuruba | Zendy; Yulia P. Korkach | Zendy; L. I. Kolchinskaya | Zendy; Valentiosar | Zendy; Bronislav L. Gavenauskas | Zendy; Zoya Serebrovska | Zendy; Man'kovs'ka Im | Zendy; Vadim F. Sagach | Zendy

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The Effect Of NO Donor on Calcium Uptake and Reactive Nitrogen Species Production in Mitochondria

Author(s) -

Akopova Ov,

Anatoly Kotsiuruba,

Yulia P. Korkach,

L. I. Kolchinskaya,

Valentiosar,

Bronislav L. Gavenauskas,

Zoya Serebrovska,

Man'kovs'ka Im,

Vadim F. Sagach

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445616

Subject(s) - nitric oxide , mptp , chemistry , reactive nitrogen species , mitochondrion , mitochondrial permeability transition pore , calcium , biochemistry , nitric oxide synthase , citrulline , reactive oxygen species , biophysics , uniporter , arginine , enzyme , biology , programmed cell death , endocrinology , cytosol , apoptosis , dopaminergic , organic chemistry , amino acid , dopamine

NO and reactive nitrogen species (RNS) are thought to be physiologically important effectors of mitochondrial calcium transport, but this issue was not studied in a living organism. According to literature, the modulation of Ca2+ uptake could influence RNS production via the action on mitochondrial NO synthase (mtNOS). The aim of this work was to study the effect of in vivo administration of NO donor nitroglycerine (NG) on matrix Ca2+ accumulation, RNS production and mtNOS activity.

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