Inhibition of CPU0213, a Dual Endothelin Receptor Antagonist, on Apoptosis via Nox4-Dependent ROS in HK-2 Cells | Zendy

Qing Li | Zendy; Ji Li | Zendy; Hua Shao | Zendy; Xiaoxue Li | Zendy; Feng Yu | Zendy; Ming Xu | Zendy

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Inhibition of CPU0213, a Dual Endothelin Receptor Antagonist, on Apoptosis via Nox4-Dependent ROS in HK-2 Cells

Author(s) -

Qing Li,

Ji Li,

Hua Shao,

Xiaoxue Li,

Feng Yu,

Ming Xu

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445615

Subject(s) - nox4 , apoptosis , receptor , endothelin 1 , diabetic nephropathy , annexin , microbiology and biotechnology , endothelin receptor , endocrinology , medicine , biology , oxidative stress , chemistry , nadph oxidase , kidney , biochemistry

Our previous studies have indicated that a novel endothelin receptor antagonist CPU0213 effectively normalized renal function in diabetic nephropathy. However, the molecular mechanisms mediating the nephroprotective role of CPU0213 remain unknown.

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