Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro | Zendy

Haijie Yu | Zendy; Haishan Zhang | Zendy; Weihua Zhao | Zendy; Liang Guo | Zendy; Xueyuan Li | Zendy; Yang Li | Zendy; Xingang Zhang | Zendy; Yingxian Sun | Zendy

Open Access

Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro

Author(s) -

Haijie Yu,

Haishan Zhang,

Weihua Zhao,

Liang Guo,

Xueyuan Li,

Yang Li,

Xingang Zhang,

Yingxian Sun

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445611

Subject(s) - pi3k/akt/mtor pathway , chop , protein kinase b , pharmacology , apoptosis , reperfusion injury , medicine , creatine kinase , lactate dehydrogenase , cardiac function curve , in vivo , ischemia , chemistry , biology , biochemistry , heart failure , enzyme , microbiology and biotechnology

Ischemia-reperfusion (I/R) injury is believed to be the major cause for detriments in coronary heart diseases, but few effective therapies for prevention or treatment of I/R injury are available. Gypenoside (GP) is the predominant effective component of Gynostemma pentaphyllum and possesses capacities against inflammation and oxidation. In the present study, the role of GP in ameliorating myocardial I/R injury was investigated.

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