Probucol Protects Endothelial Progenitor Cells Against Oxidized Low-Density Lipoprotein via Suppression of Reactive Oxygen Species Formation In Vivo | Zendy

Qingbin Zhang | Zendy; Liming Chen | Zendy; Zhihua Si | Zendy; Haoran Bu | Zendy; Chandrakala Aluganti Narasimhulu | Zendy; Xueling Song | Zendy; Mingyu Cui | Zendy; Hang Liu | Zendy; Tiewei Lu | Zendy; Guanglong He | Zendy; Sampath Parthasarathy | Zendy; Lianqun Cui | Zendy; Zhenguo Liu | Zendy; Yuqi Cui | Zendy

Open Access

Probucol Protects Endothelial Progenitor Cells Against Oxidized Low-Density Lipoprotein via Suppression of Reactive Oxygen Species Formation In Vivo

Author(s) -

Qingbin Zhang,

Liming Chen,

Zhihua Si,

Haoran Bu,

Chandrakala Aluganti Narasimhulu,

Xueling Song,

Mingyu Cui,

Hang Liu,

Tiewei Lu,

Guanglong He,

Sampath Parthasarathy,

Lianqun Cui,

Zhenguo Liu,

Yuqi Cui

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445608

Subject(s) - probucol , reactive oxygen species , in vivo , progenitor cell , chemistry , microbiology and biotechnology , endothelial progenitor cell , endothelial stem cell , low density lipoprotein , progenitor , lipoprotein , oxygen , biochemistry , biophysics , in vitro , cholesterol , biology , stem cell , organic chemistry

Oxidized low-density lipoprotein (ox-LDL) is a major component of hyperlipidemia and contributes to atherosclerosis. Endothelial progenitor cells (EPCs) play an important role in preventing atherosclerosis and notably decreased in hyperlipidemia. Ox-LDL and ox-LDL-related reactive oxygen species (ROS) have deleterious effects on EPCs. Probucol as an antioxidant and anti-inflammatory drug reduces ROS production. The present study was to determine if probucol could protect EPCs from ox-LDL in vivo and to investigate the potential mechanisms.

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