Upregulation of Periostin Prevents High Glucose-Induced Mitochondrial Apoptosis in Human Umbilical Vein Endothelial Cells via Activation of Nrf2/HO-1 Signaling | Zendy

Zhiying Zhong | Zendy; Yu Tang | Zendy

Open Access

Upregulation of Periostin Prevents High Glucose-Induced Mitochondrial Apoptosis in Human Umbilical Vein Endothelial Cells via Activation of Nrf2/HO-1 Signaling

Author(s) -

Zhiying Zhong,

Yu Tang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445606

Subject(s) - periostin , downregulation and upregulation , umbilical vein , microbiology and biotechnology , apoptosis , reactive oxygen species , mitochondrial ros , chemistry , oxidative stress , biology , cancer research , biochemistry , in vitro , extracellular matrix , gene

High glucose-induced oxidative damage to endothelial cells plays a central role in the pathogenesis of diabetic vascular complications. This study was undertaken to explore the role of periostin in high glucose-induced endothelial cell apoptosis and associated molecular mechanisms.

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