Amlodipine and Atorvastatin Improved Hypertensive Cardiac Remodeling through Regulation of MMPs/TIMPs in SHR Rats | Zendy

Jingchao Lu | Zendy; Jie Hao | Zendy; Hong Du | Zendy; Bing Xiao | Zendy; Yue Li | Zendy; Xiuchun Yang | Zendy; Wei Cui | Zendy

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Amlodipine and Atorvastatin Improved Hypertensive Cardiac Remodeling through Regulation of MMPs/TIMPs in SHR Rats

Author(s) -

Jingchao Lu,

Jie Hao,

Hong Du,

Bing Xiao,

Yue Li,

Xiuchun Yang,

Wei Cui

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445604

Subject(s) - amlodipine , atorvastatin , matrix metalloproteinase , medicine , cardiology , endocrinology , pharmacology , blood pressure

MMPs/TIMPs system is well known to play important roles in pressure overload-induced cardiac remodeling, and Amlodipine and Atorvastatin have been showed to exert favourable protective effects on cardiovascular disease, however, it is not clear whether Amlodipine and Atorvastatin can improve hypertensive cardiac remodeling and whether the MMPs/TIMPs system is involved. The present study aims to answer these questions.

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