Targeting of Survivin Pathways by YM155 Inhibits Cell Death and Invasion in Oral Squamous Cell Carcinoma Cells | Zendy

Wei Zhang | Zendy; Yuan Liu | Zendy; Yufeng Li | Zendy; Yun Yue | Zendy; Xinghua Yang | Zendy; Peng Lin | Zendy

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Targeting of Survivin Pathways by YM155 Inhibits Cell Death and Invasion in Oral Squamous Cell Carcinoma Cells

Author(s) -

Wei Zhang,

Yuan Liu,

Yufeng Li,

Yun Yue,

Xinghua Yang,

Peng Lin

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445594

Subject(s) - survivin , cancer research , programmed cell death , basal cell , cell , apoptosis , cell growth , microbiology and biotechnology , chemistry , medicine , biology , pathology , biochemistry

Specific overexpression in cancer cells and evidence of oncogenic functions make Survivin an attractive target in cancer therapy. The small molecule compound YM155 has been described as the first "Survivin suppressant" but molecular mechanisms involved in its biological activity and its clinical potential remain obscure. Survivin protein plays critical roles in oral squamous cell carcinoma (OSCC), suggesting that YM155 would be extremely valuable for OSCC. In this study, we tested our hypothesis whether YM155 could be an effective inhibitor of cell growth, invasion and angiogenesis in oral squamous cell carcinoma (OSCC) cells.

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