An Inhibitory Role of Osthole in Rat MSCs Osteogenic Differentiation and Proliferation via Wnt/β-Catenin and Erk1/2-MAPK Pathways | Zendy

Hongyang Hu | Zendy; Min Chen | Zendy; Guangzu Dai | Zendy; Guoqing Du | Zendy; Xuezong Wang | Zendy; Jie He | Zendy; Yongfang Zhao | Zendy; Dapeng Han | Zendy; Yuelong Cao | Zendy; Yuxin Zheng | Zendy; Dao-Fang Ding | Zendy

Open Access

An Inhibitory Role of Osthole in Rat MSCs Osteogenic Differentiation and Proliferation via Wnt/β-Catenin and Erk1/2-MAPK Pathways

Author(s) -

Hongyang Hu,

Min Chen,

Guangzu Dai,

Guoqing Du,

Xuezong Wang,

Jie He,

Yongfang Zhao,

Dapeng Han,

Yuelong Cao,

Yuxin Zheng,

Dao-Fang Ding

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445590

Subject(s) - wnt signaling pathway , mesenchymal stem cell , mapk/erk pathway , microbiology and biotechnology , chemistry , cyclin d1 , cell growth , alkaline phosphatase , pi3k/akt/mtor pathway , catenin , signal transduction , cellular differentiation , protein kinase b , blot , cell , biology , cell cycle , biochemistry , gene , enzyme

Bone marrow-derived mesenchymal stem cells (MSCs) are responsible for new bone formation during adulthood. Accumulating evidences showed that Osthole promotes the osteogenic differentiation in primary osteoblasts. The aim of this study was to investigate whether Osthole exhibits a potential to stimulate the osteogenic differentiation of MSCs and the underlying mechanism.

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