Anidulafungin-Induced Suicidal Erythrocyte Death | Zendy

Thomas Peter | Zendy; Rosi Bissinger | Zendy; Guilai Liu | Zendy; Florian Läng | Zendy

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Anidulafungin-Induced Suicidal Erythrocyte Death

Author(s) -

Thomas Peter,

Rosi Bissinger,

Guilai Liu,

Florian Läng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445582

Subject(s) - anidulafungin , phosphatidylserine , protein kinase c , biology , oxidative stress , apoptosis , nitric oxide , protein kinase a , reactive oxygen species , annexin , kinase , pharmacology , microbiology and biotechnology , chemistry , biochemistry , endocrinology , phospholipid , fluconazole , membrane , antifungal , micafungin

The novel antifungal drug Anidulafungin is used for the treatment of diverse fungal infections including candidiasis and aspergillosis. The traditional antifungal drug amphotericin B has previously been shown to trigger eryptosis, the suicidal death of erythrocytes characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Triggers of eryptosis include increase of cytosolic Ca2+ activity ([Ca2+]i), oxidative stress, ceramide, activated protein kinase C (PKC), casein kinase 1α or p38 kinase and activated caspases. Inhibitors of eryptosis include nitric oxide (NO). The present study explored, whether Anidulafungin induces eryptosis.

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