Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma | Zendy

Lu Wang | Zendy; Yang Lei | Zendy; Ying Lu | Zendy; Yingzhun Chen | Zendy; Tianhua Liu | Zendy; Yanli Peng | Zendy; Yuhong Zhou | Zendy; Yang Cao | Zendy; Zhenggang Bi | Zendy; Tianyi Liu | Zendy; Liu Zhen-hong | Zendy; Hongli Shan | Zendy

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Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma

Author(s) -

Lu Wang,

Yang Lei,

Ying Lu,

Yingzhun Chen,

Tianhua Liu,

Yanli Peng,

Yuhong Zhou,

Yang Cao,

Zhenggang Bi,

Tianyi Liu,

Liu Zhen-hong,

Hongli Shan

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445573

Subject(s) - pten , protein kinase b , osteosarcoma , cancer research , viability assay , cell cycle , apoptosis , cell growth , pi3k/akt/mtor pathway , cell cycle checkpoint , signal transduction , cell migration , mtt assay , chemistry , cell , biology , microbiology and biotechnology , biochemistry

Osteosarcoma is the second highest cause of cancer-related death in children and adolescents. Majority of osteosarcoma patients (90%) show metastasis. Previous reports revealed that osthole showed antitumor activities via induction of apoptosis and inhibition of proliferation. However, the potential effects and detailed molecular mechanisms involved remained unclear.

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