Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis | Zendy

Shaghayegh Tavakoli Tabazavareh | Zendy; Aaron P. Seitz | Zendy; Peter L. Jernigan | Zendy; Carolin Sehl | Zendy; Simone Keitsch | Zendy; Stephan Lang | Zendy; Barbara C. Kahl | Zendy; Michael J. Edwards | Zendy; Heike Grassmé | Zendy; Erich Gulbins | Zendy; Katrin Anne Becker | Zendy

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Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis

Author(s) -

Shaghayegh Tavakoli Tabazavareh,

Aaron P. Seitz,

Peter L. Jernigan,

Carolin Sehl,

Simone Keitsch,

Stephan Lang,

Barbara C. Kahl,

Michael J. Edwards,

Heike Grassmé,

Erich Gulbins,

Katrin Anne Becker

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445567

Subject(s) - staphylococcus aureus , sphingosine , ceramide , microbiology and biotechnology , cystic fibrosis , pseudomonas aeruginosa , respiratory tract , biology , medicine , respiratory system , immunology , bacteria , receptor , biochemistry , apoptosis , genetics

Pulmonary Staphylococcus aureus (S. aureus) infections occur early in a high percentage of cystic fibrosis (CF) patients and it is believed that these infections facilitate further colonization of CF lungs with Pseudomonas aeruginosa (P. aeruginosa). Previous studies demonstrated a marked reduction of sphingosine in tracheal and bronchial epithelial cells in CF compared to wild type mice, while ceramide is massively increased in CF mice.

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