How to Distinguish between Statistically Significant Results and Clinically Relevant Results | Zendy

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How to Distinguish between Statistically Significant Results and Clinically Relevant Results

Author(s) -

Derrick Bennett

Publication year - 2016

Publication title -

monographs in clinical neuroscience/frontiers of neurology and neuroscience/monographs in neural sciences

Language(s) - English

Resource type - Journals

eISSN - 1420-2441

pISSN - 0300-5186

DOI - 10.1159/000445411

Subject(s) - generalizability theory , clinical trial , medicine , dilemma , randomized controlled trial , relevance (law) , medical physics , psychology , pathology , epistemology , developmental psychology , political science , law , philosophy

A practicing clinician will often be confronted with the results of a new clinical trial in their relevant field and will be faced with the dilemma of determining whether these results are clinically relevant to their own work. This chapter aims to describe the concepts of statistical significance in randomized clinical trials from a mainly classical statistical inference perspective. This chapter describes approaches to assess clinical significance and illustrates these approaches with examples from the contemporary neurological literature.

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