The Clinicopathologic Heterogeneity of Grade 3 Gastroenteropancreatic Neuroendocrine Neoplasms: Morphological Differentiation and Proliferation Identify Different Prognostic Categories | Zendy

Massimo Milione | Zendy; Patrick Maisonneuve | Zendy; Francesca Spada | Zendy; Alessio Pellegrinelli | Zendy; Paola Spaggiari | Zendy; Luca Albarello | Zendy; Eleonora Pisa | Zendy; Massimo Barberis | Zendy; Alessandro Vanoli | Zendy; Roberto Buzzoni | Zendy; Sara Pusceddu | Zendy; Laura Concas | Zendy; Fausto Sessa | Zendy; Enrico Solcia | Zendy; Carlo Capella | Zendy; Nicola Fazio | Zendy; Stefano La Rosa | Zendy

Open Access

The Clinicopathologic Heterogeneity of Grade 3 Gastroenteropancreatic Neuroendocrine Neoplasms: Morphological Differentiation and Proliferation Identify Different Prognostic Categories

Author(s) -

Massimo Milione,

Patrick Maisonneuve,

Francesca Spada,

Alessio Pellegrinelli,

Paola Spaggiari,

Luca Albarello,

Eleonora Pisa,

Massimo Barberis,

Alessandro Vanoli,

Roberto Buzzoni,

Sara Pusceddu,

Laura Concas,

Fausto Sessa,

Enrico Solcia,

Carlo Capella,

Nicola Fazio,

Stefano La Rosa

Publication year - 2016

Publication title -

neuroendocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.493

H-Index - 101

eISSN - 1423-0194

pISSN - 0028-3835

DOI - 10.1159/000445165

Subject(s) - cd117 , proliferation index , ki 67 , proportional hazards model , univariate analysis , pathology , medicine , proliferative index , neuroendocrine differentiation , stage (stratigraphy) , survival analysis , neuroendocrine tumors , multivariate analysis , oncology , gastroenterology , immunohistochemistry , biology , cancer , cd34 , paleontology , genetics , stem cell , prostate cancer

Gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) are defined as neuroendocrine neoplasms (NENs) with a Ki-67 index >20% according to the 2010 WHO classification. Some reports suggest that this category is heterogeneous. We retrospectively studied a series of 136 patients affected by grade 3 GEP-NECs with the aim to clarify the prognostic role of tumor morphological differentiation, proliferation, defect in mismatch repair proteins (MMRd), CD117 expression, and site of origin. The primary endpoint was the correlation between these parameters and the overall survival (OS).

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