Treatment of Locally Advanced Pancreatic Ductal Adenocarcinoma | Zendy

Andrew P. Loehrer | Zendy; Cristina R. Ferrone | Zendy

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Treatment of Locally Advanced Pancreatic Ductal Adenocarcinoma

Author(s) -

Andrew P. Loehrer,

Cristina R. Ferrone

Publication year - 2016

Publication title -

digestive surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.762

H-Index - 69

eISSN - 1421-9983

pISSN - 0253-4886

DOI - 10.1159/000445020

Subject(s) - medicine , pancreatic ductal adenocarcinoma , pancreatic cancer , chemotherapy , adenocarcinoma , oncology , neoadjuvant therapy , surgical resection , cancer , general surgery , breast cancer

Pancreatic ductal adenocarcinoma (PDAC) is increasingly common and a leading cause of cancer-related mortality. Surgery remains the only possibility for cure. Upwards of 40% of patients present with locally advanced PDAC (LA-PDAC), where management strategies continue to evolve. In this review, we highlight current trends in neoadjuvant chemotherapy, surgical resection, and other multimodality approaches for patients with LA-PDAC. Despite promising early results, additional work is needed to more accurately and appropriately tailor treatment for patients with LA-PDAC.

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