MLC901 Favors Angiogenesis and Associated Recovery after Ischemic Stroke in Mice | Zendy

Carine Gandin | Zendy; Catherine Widmann | Zendy; Michel Lazdunski | Zendy; Catherine Heurteaux | Zendy

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MLC901 Favors Angiogenesis and Associated Recovery after Ischemic Stroke in Mice

Author(s) -

Carine Gandin,

Catherine Widmann,

Michel Lazdunski,

Catherine Heurteaux

Publication year - 2016

Publication title -

cerebrovascular diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.221

H-Index - 104

eISSN - 1421-9786

pISSN - 1015-9770

DOI - 10.1159/000444810

Subject(s) - medicine , angiogenesis , neuroprotection , ischemia , arteriogenesis , stroke (engine) , therapeutic angiogenesis , erythropoietin , collateral circulation , infarction , revascularization , vascular endothelial growth factor , neovascularization , brain ischemia , myocardial infarction , vegf receptors , mechanical engineering , engineering

There is increasing evidence that angiogenesis, through new blood vessel formation, results in improved collateral circulation and may impact the long-term recovery of patients. In this study, we first investigated the preventive action of a 5-week pretreatment of MLC901, an herbal extract preparation derived from Chinese medicine, against the deleterious effects of ischemic stroke and its effects on angiogenesis in a model of focal ischemia in mice.

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