Calreticulin Regulates Neointima Formation and Collagen Deposition following Carotid Artery Ligation | Zendy

Kurt A. Zimmerman | Zendy; Dongqi Xing | Zendy; Manuel A. Pallero | Zendy; Ailing Lu | Zendy; Masahito Ikawa | Zendy; Leland L. Black | Zendy; Kenneth Hoyt | Zendy; Janusz H. Kabarowski | Zendy; Marek Michalak | Zendy; Joanne E. Murphy-Ullrich | Zendy

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Calreticulin Regulates Neointima Formation and Collagen Deposition following Carotid Artery Ligation

Author(s) -

Kurt A. Zimmerman,

Dongqi Xing,

Manuel A. Pallero,

Ailing Lu,

Masahito Ikawa,

Leland L. Black,

Kenneth Hoyt,

Janusz H. Kabarowski,

Marek Michalak,

Joanne E. Murphy-Ullrich

Publication year - 2015

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000443884

Subject(s) - neointima , microbiology and biotechnology , extracellular matrix , gene knockdown , chemistry , biology , medicine , apoptosis , restenosis , biochemistry , stent

The endoplasmic reticulum (ER) stress protein, calreticulin (CRT), is required for the production of TGF-β-stimulated extracellular matrix (ECM) by fibroblasts. Since TGF-β regulates vascular fibroproliferative responses and collagen deposition, we investigated the effects of CRT knockdown on vascular smooth-muscle cell (VSMC) fibroproliferative responses and collagen deposition.

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