Semaphorins and Plexins in Kidney Disease
Author(s) -
Jingjing Xia,
Thomas Worzfeld
Publication year - 2016
Publication title -
the nephron journals/nephron journals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.951
H-Index - 72
eISSN - 2235-3186
pISSN - 1660-8151
DOI - 10.1159/000443645
Subject(s) - semaphorin , pathophysiology , medicine , transmembrane protein , disease , kidney , kidney disease , receptor , immunology , pathology
Semaphorins are soluble or membrane-bound cues, which control multiple aspects of cell-cell communication, differentiation, morphology and function. Most of their effects are mediated by a family of transmembrane receptors called plexins. Semaphorins and plexins have emerged as central regulators of diverse physiological and pathophysiological processes in various organs. This review summarizes the role of semaphorins and plexins in renal pathophysiology and their potential use as biomarkers of kidney disease.
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