Rhinosinusal Inflammation and High Mobility Group Box 1 Protein: A New Target for Therapy | Zendy

Luisa Bellussi | Zendy; Serena Cocca | Zendy; Lei Chen | Zendy; Francesco Maria Passàli | Zendy; Condrut Sarafoleanu | Zendy; Desiderio Passàli | Zendy

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Rhinosinusal Inflammation and High Mobility Group Box 1 Protein: A New Target for Therapy

Author(s) -

Luisa Bellussi,

Serena Cocca,

Lei Chen,

Francesco Maria Passàli,

Condrut Sarafoleanu,

Desiderio Passàli

Publication year - 2016

Publication title -

orl

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.481

H-Index - 44

eISSN - 1423-0275

pISSN - 0301-1569

DOI - 10.1159/000443481

Subject(s) - hmgb1 , inflammation , immunology , pathogenesis , medicine , western blot , nasal polyps , immunofluorescence , sinusitis , antibody , biology , biochemistry , gene

High mobility group box 1 (HMGB1) is a protein belonging to the class of damage-associated molecular pattern molecules, which activates innate immunity and powerful inflammatory factors. The aim of this review is to show the importance of HMGB1 in the pathogenesis of nasal inflammatory diseases and to suggest that inhibition of HMGB1 may be an innovative therapeutic target.

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