Haploidentical Donors: Can Faster Transplantation Be Life-Saving for Patients with Advanced Disease? | Zendy

Alina Tănase | Zendy; Ciprian Tomuleasa | Zendy; Alexandra Mărculescu | Zendy; Alexandru Bardaş | Zendy; Anca Coliţă | Zendy; Carmen Orban | Zendy; Stefan O. Ciurea | Zendy

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Haploidentical Donors: Can Faster Transplantation Be Life-Saving for Patients with Advanced Disease?

Author(s) -

Alina Tănase,

Ciprian Tomuleasa,

Alexandra Mărculescu,

Alexandru Bardaş,

Anca Coliţă,

Carmen Orban,

Stefan O. Ciurea

Publication year - 2016

Publication title -

acta haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 56

eISSN - 1421-9662

pISSN - 0001-5792

DOI - 10.1159/000443469

Subject(s) - medicine , transplantation , cyclophosphamide , stem cell , disease , incidence (geometry) , graft versus host disease , human leukocyte antigen , hematopoietic stem cell transplantation , surgery , immunology , chemotherapy , biology , antigen , genetics , physics , optics

Haploidentical stem cell transplantation is a therapeutic option for patients without an HLA-matched donor. It is increasingly being used worldwide due to the application of posttransplantation cyclophosphamide and is associated with lower incidence of graft-versus-host disease and treatment-related mortality. Haploidentical donors are generally available for most patients and stem cells can be rapidly obtained. Delays in transplantation while waiting for unrelated donor cells can be potentially problematic for patients with advanced disease at risk for progression; thus, the use of haploidentical donors, especially in this setting, can be life-saving. Here we reviewed the literature on haploidentical stem cell transplantation performed with posttransplantation cyclophosphamide.

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