Effects of Dendritic Cell Subset Manipulation on Airway Allergy in a Mouse Model | Zendy

Ryosuke Murakami | Zendy; Yohko Nakagawa | Zendy; Masumi Shimizu | Zendy; Ayako Wakabayashi | Zendy; Yasuyuki Negishi | Zendy; Takachika Hiroi | Zendy; Kimihiro Okubo | Zendy; Hidemi Takahashi | Zendy

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Effects of Dendritic Cell Subset Manipulation on Airway Allergy in a Mouse Model

Author(s) -

Ryosuke Murakami,

Yohko Nakagawa,

Masumi Shimizu,

Ayako Wakabayashi,

Yasuyuki Negishi,

Takachika Hiroi,

Kimihiro Okubo,

Hidemi Takahashi

Publication year - 2015

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000443237

Subject(s) - immunology , immunoglobulin e , immune system , bronchoalveolar lavage , medicine , histamine , nasal administration , allergy , dendritic cell , antibody , lung , pharmacology

Two major distinct subsets of dendritic cells (DCs) are arranged to regulate immune responses: DEC-205+ DCs drive Th1 polarization and 33D1+ DCs establish Th2 dominancy. Th1 polarization can be achieved either by depletion of 33D1+ DCs with a 33D1-specific monoclonal antibody (mAb) or by activation of DEC-205+ DCs via intraperitoneal injection of α-galactosylceramide (α-GalCer). We studied the effect of 33D1+ DC depletion or DEC-205+ DC activation in vivo using an established mouse model of allergic rhinitis (AR).

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