Induction of Microglial Activation by Mediators Released from Mast Cells | Zendy

Xiang Zhang | Zendy; Yiming Wang | Zendy; Hongquan Dong | Zendy; Ying Xu | Zendy; Shu Zhang | Zendy

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Induction of Microglial Activation by Mediators Released from Mast Cells

Author(s) -

Xiang Zhang,

Yiming Wang,

Hongquan Dong,

Ying Xu,

Shu Zhang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443093

Subject(s) - microglia , mast cell , microbiology and biotechnology , immune system , biology , tumor necrosis factor alpha , inflammation , receptor , immunology , biochemistry

Microglia are the resident immune cells in the brain and play a pivotal role in immune surveillance in the central nervous system (CNS). Brain mast cells are activated in CNS disorders and induce the release of several mediators. Thus, brain mast cells, rather than microglia, are the "first responders" due to injury. However, the functional aspects of mast cell-microglia interactions remain uninvestigated.

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