Protective Effects of Cerium Oxide Nanoparticles on MC3T3-E1 Osteoblastic Cells Exposed to X-Ray Irradiation | Zendy

Cuifen Wang | Zendy; Eric Blough | Zendy; Xiaoniu Dai | Zendy; Omolola Olajide | Zendy; Henry K. Driscoll | Zendy; John W. Leidy | Zendy; Mose July | Zendy; William E. Triest | Zendy; Miaozong Wu | Zendy

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Protective Effects of Cerium Oxide Nanoparticles on MC3T3-E1 Osteoblastic Cells Exposed to X-Ray Irradiation

Author(s) -

Cuifen Wang,

Eric Blough,

Xiaoniu Dai,

Omolola Olajide,

Henry K. Driscoll,

John W. Leidy,

Mose July,

William E. Triest,

Miaozong Wu

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443092

Subject(s) - viability assay , micronucleus test , reactive oxygen species , chemistry , irradiation , cerium oxide , micronucleus , alkaline phosphatase , biophysics , osteoblast , extracellular , cell growth , cell , toxicity , biochemistry , biology , in vitro , enzyme , physics , organic chemistry , nuclear physics , catalysis

Exposure to ionizing radiation can result in bone damage, including decreased osteocyte number and suppressed osteoblastic activity. However, molecular mechanisms remain to be elucidated, and effective prevention strategies are still limited. This study was to investigate whether cerium oxide nanoparticles (CeO2 NP) can protect MC3T3-E1 osteoblast-like cells from damaging effects of X-ray irradiation, and to study the underpinning mechanism(s).

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