Stimulating Effect of Terfenadine on Erythrocyte Cell Membrane Scrambling | Zendy

Elena Signoretto | Zendy; Michela Castagna | Zendy; Abdulla Al Mamun Bhuyan | Zendy; Florian Läng | Zendy

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Stimulating Effect of Terfenadine on Erythrocyte Cell Membrane Scrambling

Author(s) -

Elena Signoretto,

Michela Castagna,

Abdulla Al Mamun Bhuyan,

Florian Läng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443085

Subject(s) - terfenadine , phosphatidylserine , ceramide , chemistry , annexin , biophysics , apoptosis , extracellular , ionomycin , phospholipid scramblase , biochemistry , annexin a5 , microbiology and biotechnology , pharmacology , biology , intracellular , membrane , phospholipid

The antihistaminic drug Terfenadine may trigger apoptosis of tumor cells, an effect unrelated to its effect on histamine receptors. Similar to apoptosis of nucleated cells, erythrocytes may enter eryptosis, the suicidal death of erythrocytes characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Signaling triggering eryptosis include increase of cytosolic Ca2+ activity ([Ca2+]i), oxidative stress, and ceramide. The present study explored, whether Terfenadine is capable to trigger eryptosis.

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