Phosphatidylserine Exposure in Human Red Blood Cells Depending on Cell Age | Zendy

Mauro C. Wesseling | Zendy; Lisa Wagner-Britz | Zendy; Henri Huppert | Zendy; Benjamin Hanf | Zendy; Laura Hertz | Zendy; Duc Bach Nguyen | Zendy; Ingolf Bernhardt | Zendy

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Phosphatidylserine Exposure in Human Red Blood Cells Depending on Cell Age

Author(s) -

Mauro C. Wesseling,

Lisa Wagner-Britz,

Henri Huppert,

Benjamin Hanf,

Laura Hertz,

Duc Bach Nguyen,

Ingolf Bernhardt

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443081

Subject(s) - phosphatidylserine , percoll , lysophosphatidic acid , intracellular , incubation , protein kinase c , flow cytometry , red blood cell , apoptosis , centrifugation , chemistry , incubation period , microbiology and biotechnology , biology , phospholipid , biochemistry , kinase , membrane , receptor

The exposure of phosphatidylserine (PS) on the outer membrane leaflet of red blood cells (RBCs) serves as a signal for suicidal erythrocyte death or eryptosis, which may be of importance for cell clearance from blood circulation. PS externalisation is realised by the scramblase activated by an increase of intracellular Ca2+ content. It has been described in literature that RBCs show an increased intracellular Ca2+ content as well as PS exposure when becoming aged up to 120 days (which is their life span). However, these investigations were carried out after incubation of the RBCs for 48 h. The aim of this study was to investigate this effect after short-time incubation using a variety of stimulating substances for Ca2+ uptake and PS exposure.

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